Risk of Breast and Ovarian Cancer in Women With Strong Family Histories
نویسندگان
چکیده
When evaluating patients for possible deleterious BRCA mutations, determining ancestry may be a critical issue. Founder mutations are present in ethnically isolated populations and are responsible for a significant proportion of breast and ovarian cancer cases attributed to an inherited susceptibility. Founder mutations have been identified in Ashkenazi Jews,[1-3] French Canadians,[4] Japanese,[5] Italians,[6] Swedes,[7] Finns,[8] Belgians, and Dutch.[9,10]
منابع مشابه
Participation Rate, Family Histories, Symptoms, and Incidence of Breast Cancer in the Screening Program for Breast Cancer in the Population Covered by Arak Health Centers
Introduction: Breast cancer is the most common cancer in women. The present study aimed to assess the incidence, family histories, and symptoms of breast cancer among the 30–70-year-old women under the coverage of the health centers of Arak city, as well as evaluating the rate of participation in breast cancer screening. Methods: The present cross-sectional study was conducted during 2016-2019 ...
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Women who inherit mutations in the BRCA1 and BRCA2 genes may have high lifetime risks for breast and ovarian cancer regardless of whether they have a family history of the cancers. That finding comes from the New York Breast Cancer Study (NYBCS), the most thorough analysis to date of cancer risks among women who carry the mutations. Risk levels found in the NYBCS are similar to those reported i...
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متن کاملRisk of breast and ovarian cancer in women with strong family histories.
Assessing the risk of breast and ovarian cancer starts with obtaining a complete and accurate family history. This can reveal evidence of inherited cancer risk. The highest risk of cancer is associated with germ-line abnormalities in several genes, including BRCA1, BRCA2, and TP53. Moderate-risk genes associated with syndromes that are inherited in an autosomal dominant pattern (such as Cowden'...
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We ascertained 184 Ashkenazi Jewish women with breast/ovarian cancer (171 breast and 13 ovarian cancers, two of the former also had ovarian cancer) in a self-referral study. They were tested for germline founder mutations in BRCA1 (185delAG, 5382insC, 188del11) and BRCA2 (6174delT). Personal/family histories were correlated with mutation status. Logistic regression was used to develop a model t...
متن کاملThe Effect of Stress Management Group Counseling on Stress in Women with a Family History of Breast Cancer
Background & Aims: Breast cancer is the most prevalent cancer and the leading cause of death due to cancer in woman. The presence of a breast cancer patient in the family not only increases the risk of this cancer among family members, but can also increase their stress level. Moreover, increased stress level can be proposed as a trigger for breast cancer. The aim of the presen...
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تاریخ انتشار 2017